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News Americas

UC San Diego neurosurgeons color code the brain with tractography. The circular object is a tumor. (Photo: University of California)
Dec 4, 2013 | News Americas

Brain surgery: Water-based imaging technique maps neurons prior to surgery

by Surgical Tribune (PR)

SAN DIEGO, USA: American neurosurgeons are using a new approach to visualize the brain's delicate anatomy prior to surgery. The novel technique allows them to see the brain's nerve connections in order to preserve and protect critical functions such as vision, speech and memory. No needles, dyes or chemicals are needed for the radiology scan.

"The brain can be mapped by tracking the movement of its water molecules," said Dr. Clark Chen, neurosurgeon and vice chairman of neurosurgery at UC San Diego Health System, an academic health system composed of several medical centers, as well as other primary and specialty practices of UC San Diego Medical Group located throughout Southern California.

"Water molecules in brain nerves move in an oriented manner. However, outside the nerves, the molecules move randomly. Neurosurgeons at UC San Diego Health System can use these distinct properties to locate important connections and to guide where surgery should occur or not."

The technique, called tractography, has been used for investigational and diagnostic purposes to better understand the effect of stroke and neurological diseases, such as Alzheimer's. UC San Diego Health System neurosurgeons are among the first in the country to apply this technology to brain tumor surgery.

"There are no margins for error in the brain. Every centimeter of brain tissue contains millions of neural connections so every millimeter counts," said Chen. "With tractography, we can visualize the most important of these connections to avoid injury. In doing so, we will preserve the quality of life for our patients with brain cancer."

Anthony Chetti is a beneficiary of tractography-guided brain surgery. Chetti developed a tumor in the occipital lobe, the region of the brain responsible for processing visual information.

"Anytime that you are told that you can potentially lose your vision, you are scared," said Chetti. "But when Dr. Chen shared the tractography images with me and showed me how he was going to avoid injury to the connection between my eye and the occipital lobe, I was reassured."

Chetti underwent a complete excision of the brain tumor without any damage to his vision.
"When I woke up from surgery, I asked for my glasses immediately and began running systems checks. I could see the clock. I could read the words on a sign. It was immediately evident that there were no problems," said Chetti.

Tractography scans can reveal tiny open paths between nerve fibers to reach brain tumors. The scans are color-coded and display tiny neural connections. Other current imaging techniques, such as CT and MRI, cannot achieve this type of visual display.

"There is no way of predicting where these fibers would lie except with tractography," said Chen. "I believe that many brain tumor patients will benefit from tractography-guided surgery. By observing the flow of water molecules, we can visually reconstruct the complex symphony of brain connections. The resulting images are not only accurate but breathtakingly beautiful, giving us a glimpse into the extraordinary human mystery of the brain."

Chen added that this radiology application is new and that UC San Diego Health System teams are learning how best to apply the technology. Chen is actively investigating ways to optimize the use of tractography information through collaboration with world-renowned experts, including Dr. Anders M. Dale, vice chairman of radiology, and director of the newly established Center for Translational Imaging and Personalized Medicine at the University of California, San Diego School of Medicine.

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